NAM AIDSMAP UPDATE – FEBRUARY 5, 2018

News from aidsmap

Risk of some non-AIDS cancers greater for people with HIV than others over 50

The risk of several cancers increases with age for older HIV-positive people, investigators from the United States report in Clinical Infectious Diseases. HIV-positive individuals aged 50 and over had a significantly higher incidence of numerous cancers, including several not normally considered HIV-related.

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HIV-positive women starting antiretrovirals before conception have increased risk of having an infant that is small for gestational age

HIV-positive women who take combination antiretroviral therapy (cART) before conception have an increased risk of having a small for gestational age (SGA) baby, according to Dutch research published in PLOS One. Overall, HIV therapy before conception increased the risk of having an SGA infant by approximately a third. But the risk was only significant if the pre-conception regimen was based on a protease inhibitor (PI).

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Harm reduction scale-up needed to eliminate HCV in people who inject drugs, European model predicts

Elimination of hepatitis C among people who inject drugs in Europe will require simultaneous scale-up of direct-acting antiviral treatment, needle and syringe programmes (NSP) and opioid substitution treatment (OST), and a re-think of attitudes to drug policy and harm reduction in Central Europe, according to a modelling study led by researchers from the University of Bristol.

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NHS England seeks drug price cuts to eliminate hepatitis C by 2025

NHS England announced this week that it aims to eliminate hepatitis C by 2025 – if it can negotiate ‘best value for money’ deals with the pharmaceutical industry in a new round of tendering for direct-acting antivirals due to take place in February.

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Viral suppression protects against long-term liver damage caused by older HIV drugs

A history of treatment with some older antiretroviral drugs can have a lasting negative impact on liver health, German researchers report in PLOS One. They found that although co-infection with hepatitis C virus (HCV) was the strongest risk factor for liver damage, treatment with didanosine (ddI) and zidovudine (AZT) was also associated with significant liver fibrosis or cirrhosis. Neither of these drugs is now used in routine HIV care, and the study found strong evidence that viral suppression with antiretroviral therapy halved the risk of liver fibrosis in those previously exposed to the drugs.

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Women with HIV less likely to receive recommended treatments for gynaecologic cancers

The majority of HIV-positive women diagnosed with gynaecological cancer do not receive treatment recommended by cancer guidelines, according to research conducted in the United States and published in AIDS. Women whose care did not match guideline standards had poorer survival compared to women who received the recommended care. Toxicity and patient factors were the main reasons why women did not receive treatment recommended in guidelines.

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Despite numerous risk factors for HIV, a high proportion of Malawian adolescent girls and young women don’t see themselves at risk

Many adolescent girls and young women with multiple risk factors for infection with HIV do not consider themselves to be at high risk for acquiring the infection or worry about HIV, according to research conducted in Malawi and published in the Journal of Acquired Immune Deficiency Syndromes.

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Less than half of adolescent girls and young women with HIV have suppressed viral load in eastern and southern Africa

Less than half of adolescent girls and young women with HIV in some of the countries with the highest burden of HIV in sub-Saharan Africa have a fully suppressed viral load on antiretroviral treatment, well below the average for the population as a whole, findings from national surveys published in Mortality and Morbidity Weekly Reports show.

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Editors’ picks from other sources

Study finds more than half of patients worldwide don’t access HIV treatment until immune systems are severely compromised

from Science Speaks

Data from nearly a million patients starting treatment for HIV across the world over the last decade shows 55% of them accessed antiretroviral treatment only after their immune cell – or CD4 – counts had dropped below 200, leaving them extremely vulnerable to illnesses and infections.

600 people a week turned away from oversubscribed sexual health clinics at one London NHS trust

from Evening Standard

Dr Mark Lawton of the British Association of Sexual Health and HIV said the data showing hundreds of people are being turned away from clinic at Guy’s and St Thomas’ Trust alone are the “tip of the iceberg”. “The figures don’t count those who didn’t get through the doors because they were closed,” he told the Standard.

Fauci: from a practical standpoint the risk is ZERO

from I’m Still Josh

The world’s leading immunologist: Zero Risk. This is the crowning vindication of #UequalsU.

Trump’s global gag rule goes far beyond abortion, groups say

from Associated Press

President Donald Trump’s dramatic expansion of a ban on US funding to foreign organisations that promote or provide abortions has left impoverished women around the world without treatment for HIV, malaria and other diseases, health groups say, calling it “devastating” because Trump went where no administration had gone before.

Shining a light on trans women’s needs in sub-Sarahan Africa

from Avert

New research marks welcome step to make trans women in sub-Saharan Africa visible in HIV data.

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