Monthly shot could be the ‘next revolution’ in HIV therapy, replacing daily pills


The 9th International AIDS Society conference has drawn thousands of researchers to Paris this week. (Francois Guillot/AFP/Getty Images)

HIV/AIDS is no longer the death sentence it once was, but maintaining the strict regimen required to keep the virus at bay — one or more pills daily — still poses a major challenge to many people who are infected. Adherence is low among some populations, given the effort that is required to obtain, keep and store the medications.

That may soon change. On Monday, scientists reported an important advance in the development of a long-acting antiretroviral shot. According to an international study involving 309 patients, an injection that combines two drugs, cabotegravir and rilpivirine, appears to be as safe and effective at suppressing HIV as the daily oral regimen.

Writing in the Lancet, David Margolis of ViiV Healthcare, called it “the next revolution in HIV therapy.”

In the study, which was conducted at 50 centers in the United States, Germany, Canada, Spain, France and Germany, patients were begun on 20 weeks of daily oral medication. Once that medication had brought their viral loads down, they were given the shots as a “maintenance therapy.” Some were given the shot at four-week intervals and others at eight-week intervals. A control group continued to take the pills.

The majority of the patients tolerated the therapy well, though nearly everyone reported some mild to moderate pain at the injection site. The rates of some adverse events like headaches were similar across all three groups.

At 96 weeks, 84 percent of the patients in the oral medication group were able to keep their viral load suppressed, compared with 87 percent of the four-week shot group and 94 percent of the eight-week shot group.

The shots could revolutionize patient care in places like Africa, where it can be difficult for many people to get to a pharmacy regularly. But Mark A. Boyd, a professor at the University of Adelaide, wrote in a commentary piece accompanying the main article that there are trade-offs with both a pill and injection.

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